Schmallenberg orthobunyavirus , also called Schmallenberg virus , abbreviated SBV, is a virus that causes congenital malformations and stillbirths in cattle , sheep , goats , and possibly alpaca. It is considered to be most closely related to the Sathuperi and Douglas viruses. The virus is named after Schmallenberg , in North Rhine-Westphalia , Germany, from where the first definitive sample was derived. Immunity can possibly be acquired naturally against SBV.
The World Health Organization has included three bunyaviruses posing an increasing threat to human health on the Blueprint list of viruses likely to cause major epidemics and for which no, or insufficient countermeasures exist. Here, we describe a broadly applicable strategy, based on llama-derived single-domain antibodies VHHs , for the development of bunyavirus biotherapeutics. VHH building blocks were assembled into highly potent neutralizing complexes using bacterial superglue technology. The multimeric complexes were shown to reduce and prevent virus-induced morbidity and mortality in mice upon prophylactic administration.